Effects of intravenous long chain triglyceride or long/medium chain triglyceride fat emulsion on lipid mediators during ANP in rats
- VernacularTitle:静脉输注长链或中长链脂肪酸脂肪乳剂对急性坏死性胰腺炎大鼠脂质介质的影响
- Author:
Kejian HUANG
;
Tianfang HUA
;
Jincheng KONG
;
Honghui HU
;
Fuquan ZHONG
;
Yanling ZHANG
;
- Publication Type:Journal Article
- Keywords:
Acute necrotizing pancreatitis;
Fat emulsion;
Prostaglandins
- From:
Parenteral & Enteral Nutrition
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the effects of intravenous LCT or MCT/LCT fat emulsions on the lipid mediators and pancreatic histological changes in ANP rats. Methods:Forty three male SD rats were randomized to groups as follow.Group A～C were without ANP, group A:normal controls, group B:normal rats having received lipid based TPN and group C:operation control(OC) group having received the glucose fluid.Group D～F were with ANP,glucose group,Intralipid group and Lipofundin group.The amylase and prostaglandins in serum were determined in group A.Pancreatic histological examinations were also performed.In group B～F,Amylases or prostaglandins in serum were determined at 4,48 and 72 h, and pancreatic histological examination and pathological scoring were also completed. Results:Intralipid had no effects on serum prostaglandins when it was infused to normal rats.In groups of ANP,intravenous fat emulsion increased the 6 keto PGF 1? ,and PGE 2 concentration in serum at 4 h.Pancreatic hemorrhagic and fat necrosis were significantly reduced in Lipofundin group. Conclusions:Intravenous fat emulsion does not worsen the damages to pancreas in ANP.MCT/LCT fat emulsion is more suitable for patients with ANP.
