Inhibitory effects of piroxicam on the transplanted sarcoma S180 of mice and its effect on the expression of COX-2,VEGF, FGF-2 and MVD
- VernacularTitle:吡氧噻嗪对小鼠S180移植性肿瘤的抑制作用及其对COX-2及VEGF、FGF-2、MVD表达的影响
- Author:
Xueqin GAO
;
Weidong ZHANG
;
Shouqin SONG
;
Li WANG
;
Haiyan HUANG
;
- Publication Type:Journal Article
- Keywords:
piroxicam;
sarcoma 180 cells;
COX 2;
VEGF;
FGF 2;
MVD
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of piroxicam on transplanted Sarcoma S180 and the expression of COX 2,VEGF,FGF 2 and microvessel density (MVD) in tumor tissue METHODS Kunming mice were randomizedly divided into control group, FT207 positive group and 5, 2 5, 1 mg?kg -1 piroxicam groups One day after inoculation of 0 2 ml S180 cell suspension, FT207 and piroxicam were given by gastric intubation for 9 days The inhibitory rate on S180 was calculated routinely The expression of COX 2,VEGF,FGF 2 and MVD was detected by immunohistochemistry RESULTS The growth of S180 was significantly inhibited by piroxicam at the doses of 5, 2 5, 1 mg?kg -1 with the inhibitory rate of 31 4%,40 7% and 34 9% respectively The expression of COX 2 in the tumor tissue was also inhibited by piroxicam. Accordingly the expression of VEGF,FGF 2 and MVD was markedly inhibited in dose dependent manner by piroxicam CONCLUSIONS The results suggest that piroxicam has inhibitory effects on S180,and it also decreases the expression of COX 2 in tumor tissue. There is a relation ship between the expression of COX 2 and angiogenesis related factor Antiangiogenesis may be another mechanism for piroxicam to exert its chemopreventive and treatment effects.
