The pattern of choosing dialysis modality and related mortality outcomes in Korea: a national population-based study.
- Author:
Hyung Jong KIM
1
;
Jung Tak PARK
;
Seung Hyeok HAN
;
Tae Hyun YOO
;
Hyeong Cheon PARK
;
Shin Wook KANG
;
Kyoung Hoon KIM
;
Dong Ryeol RYU
;
Hyunwook KIM
Author Information
- Publication Type:Original Article
- Keywords: Renal dialysis; Peritoneal dialysis; Comorbidity; Mortality
- MeSH: Cerebrovascular Disorders; Comorbidity; Dialysis*; Heart Failure; Humans; Korea*; Logistic Models; Male; Mortality*; Myocardial Infarction; Peritoneal Dialysis; Renal Dialysis
- From:The Korean Journal of Internal Medicine 2017;32(4):699-710
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Since comorbidities are major determinants of modality choice, and also interact with dialysis modality on mortality outcomes, we examined the pattern of modality choice according to comorbidities and then evaluated how such choices affected mortality in incident dialysis patients. METHODS: We analyzed 32,280 incident dialysis patients in Korea. Patterns in initial dialysis choice were assessed by multivariate logistic regression analyses. Multivariate Poisson regression analyses were performed to evaluate the effects of interactions between comorbidities and dialysis modality on mortality and to quantify these interactions using the synergy factor. RESULTS: Prior histories of myocardial infarction (p = 0.031), diabetes (p = 0.001), and congestive heart failure (p = 0.003) were independent factors favoring the initiation with peritoneal dialysis (PD), but were associated with increased mortality with PD. In contrast, a history of cerebrovascular disease and 1-year increase in age favored initiation with hemodialysis (HD) and were related to a survival benefit with HD (p < 0.001, both). While favoring initiation with HD, having Medical Aid (p = 0.001) and male gender (p = 0.047) were related to increased mortality with HD. Furthermore, although the severity of comorbidities did not inf luence dialysis modality choice, mortality in incident PD patients was significantly higher compared to that in HD patients as the severity of comorbidities increased (p for trend < 0.001). CONCLUSIONS: Some comorbidities exerted independent effects on initial choice of dialysis modality, but this choice did not always lead to the best results. Further analyses of the pattern of choosing dialysis modality according to baseline comorbid conditions and related consequent mortality outcomes are needed.
