Effect of HLA matching measures on prevention of hyperacute rejection before kidney transplantation
- VernacularTitle:HLA系统检测预防肾移植超急排斥反应的临床研究
- Author:
Shi QIU
;
Liming ZHAO
;
Long LIU
;
Jun XIANG
;
- Publication Type:Journal Article
- Keywords:
hyperacute rejection;
lymphocytotoxic crossmatch;
HLA antigens;
panel reaction antibody;
kidney transplantation
- From:
Academic Journal of Second Military Medical University
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of 3 HLA matching measures on preventing hyperacute rejection(HAR). Methods:Among 1 152 cases,550 cases received anti donor lymphocytotoxic crossmatch(LXM),335 cases received LXM and HLA serological test,267 cases of the latter again received panel reaction antibody(PRA)test, the change of the HAR rate with different HLA matching measures were analyzed. Results:If LXM value ≤10% or HLA matched loci ≥3,the rate of HAR was unrelated to LXM value or HLA matched loci. HAR rate decreased significantly in patients with LXM and HLA serological test, and decreased more markedly in those with additional PRA test compared with those only with LXM test. Conclusion:HLA test and PRA are necessary and effective to avoid HAR.
