Effects of pioglitazone on plasma endothelin levels in patients with type 2 diabetes
- VernacularTitle:吡格列酮对2型糖尿病患者血浆内皮素水平的影响
- Author:
Jian WU
;
Dajin ZOU
;
Baohai LIU
;
- Publication Type:Journal Article
- Keywords:
pioglitazone;
endothelins;
diabetes mellitus
- From:
Academic Journal of Second Military Medical University
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of pioglitazone,a insulin sensitizing agent, on plasma endothelin levels in patients with type 2 diabetes. Methods:Type 2 diabetic patients( n =48) with moderate vascular complication, who were orally taking hypoglycemic agents:sulfonylurea and biguanides (metformin), were divided into pioglitazone group (group A, n =24) and placebo group (group B, n =24) by the rule of random and double blind. Healthy voluneers were taken as control(group C, n =20). Three months before and after treatment, fasting plasma endothelin levels and serum insulin levels were assayed by RIA. Results:(1) Before treatment, fasting plasma endothelin levels were higher in type 2 diabetic patients compared to control group( P
