Comparison of vasoconstrictive effect of histamine on the isolated rabbit central and peripheral arteries in vitro and its mechanism
- VernacularTitle:组胺对离体兔中枢和外周血管收缩作用的比较及其机理初探
- Author:
Huijing WANG
;
Aizhen WU
;
Minghui YAO
;
- Publication Type:Journal Article
- Keywords:
histamine;
diphenhydramine;
cimitidine;
nifidipine;
artery
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the effects of histamine and its antagonists on tension of isolated rabbit basilar and mesenteric artery in vitro, and to observe the role of Ca 2+ in histamine induced response. METHODS: The dose response curves induced by histamine were recorded on the isolated rabbit central and peripheral arteries in different doses of diphenhydramine, cimitidine, and nifidipine. RESULTS: Histamine could cause contraction of basilar and mesenteric isolated arteries. Diphenhydramine and nifidipine antagonized these effects, while cimitidine enhanced this effect. CONCLUSION: There may be different receptors densities in different rabbit arteries; histamine shows the vasoconstrictive effect on both brain and mesenteric arteries; and the vasoconstrictive effect mainly produces via Ca 2+ inflax.
