Effect of l-menthol on mucosa absorption of ciprofloxacin
- VernacularTitle:薄荷醇对环丙沙星粘膜吸收的影响
- Author:
Huaijun ZHAO
;
Hui WANG
;
Jianqing FENG
;
Jinshui HUANG
;
- Publication Type:Journal Article
- Keywords:
l menthol;
ciprofloxacin;
mucosa absorption;
permeation coefficient;
deposit effect
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of l menthol on the absorption of ciprofloxacin (Cip) via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0.2 percent concentration of l menthol, the decrease level was more obvious than other groups (P
