Effect of pulsating pressure on secretion of angiotensin Ⅱ by common carotid artery in rats in vivo
- VernacularTitle:脉动压力对大鼠颈总动脉血管紧张素Ⅱ分泌的影响
- Author:
Zhiqiang YAN
;
Xiangqun YANG
;
Zonglai JIANG
;
Yan ZHANG
;
- Publication Type:Journal Article
- Keywords:
pulsatile flow;
pressure;
common carotid artery;
angiotensinⅡ;
radioimmunoassay
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of pulsating pressure on secretion of angiotensin Ⅱ(AngⅡ) by common carotid artery. Methods: The common carotid arteries of rats were perfused with both high pulsating pressure (160 mmHg,1 mmHg=0.133 kPa) and normal pulsating pressure (80 mmHg) for 0.5, 1, 3 and 6 h in vivo respectively. The concentration of AngⅡ in the perfusion medium were determined by radioimmunoassay (RIA). Results: The concentration of AngⅡ in the perfusion medium of the common carotid artery increased with perfusion time. Secretion of AngⅡ was higher in 160 mmHg group than that in 80 mmHg group( P
