Effects of chloride channel blockers on KCl and 5-HT-induced contractile response at rabbit basilar artery rings
- VernacularTitle:氯通道阻断剂对KCl、5-HT引起的兔脑椎基底动脉血管环收缩效应的影响
- Author:
Yan DING
;
Yongyuan GUAN
;
Dazhi XIONG
;
Hua HE
;
- Publication Type:Journal Article
- Keywords:
basilar artery;
Ca 2+ channels;
chloride channel blockers;
KCl;
5 HT
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of different kinds of chloride channel blockers on KCl and 5 HT induced contractile responses in cerebrovascular smooth muscle. METHOD The tension of rabbit basilar artery rings was measured. RESULTS ① DIDS, furosemide and NPPB inhibited the responses to KCl and 5 HT in a concentration dependent manner. The effects of DIDS, furosemide and NPPB on the response to 5 HT were stronger than that to KCl. ②When SK&F 96365 evoked a maximum inhibitory effect on 5 HT induced response, subsequent additions of DIDS, furosemide and NPPB could further produced vascular relaxation. CONCLUSION The chloride channel participates KCl and 5 HT induced contractile responses in cerebral basilar artery.
