Improvement of the cholinergic function by melatonin in amnesic rats induced by amyloid ?-peptide 25～35
- VernacularTitle:褪黑素对痴呆大鼠胆碱能功能的修复
- Author:
Yuxian SHEN
;
Wei WEI
;
Guihong ZHANG
;
Chao LIU
;
Lihua LIU
;
Shuyun XU
;
- Publication Type:Journal Article
- Keywords:
melatonin;
amyloid beta peptide;
learning and memory;
choline acetyltransferase;
acetylcholinesterase
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate whether melatonin improve the learning and memory dysfunction in the amnesic rats induced by amyloid ? peptide 25～35 (A? 25～35 ) via cholinergic nervous system or not.Methods The amnesic model in adult rats was induced by injection of A? 25～35 into hippocampus; Morris water maze was used to determine the effects of A? 25～35 and melatonin on the learning and memory. The activity of the choline acetyltransferase and acetylcholinesterase were determined by immunohistochemistry and spectrophotometry respectively. RESULTS Injection of A? 25～35 20 ?ginto the adult rats hippocampus induced learning and memory dysfunction, and a decrease in the number of ChAT immunoreactive neurons in hippocampus. Melatonin (0 1, 1, and 10 mg?kg -1 , ig?10 d) improved the A? 25～35 treated rats cognitive function and increased the number of ChAT immunoreactive neurons in hippocampus. CONCLUSION Improvement of the cholinergic dysfunction by melatonin in adult rats induced by amyloid ? peptide 25～35 may be via cholinergic nervous system.
