Protective effects of quateranary ammonium salt derivative (F_2) of haloperidol on ischemia and reperfusion injury in rat hearts
- VernacularTitle:氟哌啶醇季铵盐衍生物对大鼠心肌缺血再灌注损伤保护作用的研究
- Author:
Zhanqin HUANG
;
Ganggang SHI
;
Caiyun CHEN
;
Weiqiu LI
;
Xizheng WU
;
Xingping LIU
;
- Publication Type:Journal Article
- Keywords:
quateranary ammonium salt derivative;
myocardial reperfusion injury;
creatine kinase isoenzyme MB;
superoxide dismutase;
malondiadehyde;
electron microscopy
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of quateranary ammonium salt derivative (F 2) of haloperidol on ischemia and reperfusion injury in rat hearts. METHODS Ischemia and reperfusion injury in rat hearts was induced by occluding the left anterior descending coronary artery for 30 min and restoring blood reperfusion for 30 min. F 2 (1, 2, 4 mg?kg -1 , respectively) was intravenously injected before heart ischemia. Plasma creatine kinase (CK), creatine kinase isoenzyme MB(CK MB), lactate dehydrogenase(LDH),? Hydroxybutyrate dehydrogenase (HBDH), grutamic oxalacetic transaminase(GOT), superoxide dismutase (SOD) activity and malondiadehyde (MDA) contents were measured. The pathologic changes of ischemia and reperfusion myocardium were observed on the transmission electron microscopy. RESULTS F 2 reduced the release of CK,CK MB LDH,HBDH,GOT from I/R rat hearts, increased the activity of SOD and decreased the MDA contents. In F 2 (1mg?kg -1 ) group, the serum CK MB LDH HBDH concentration was lowered significantly (vs I/R group P
