Effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig
- VernacularTitle:灯盏花素对豚鼠心室肌细胞迟发性外向钾电流的影响
- Author:
Lijuan WANG
;
Yong WANG
;
Jingming LI
;
- Publication Type:Journal Article
- Keywords:
current;
patch clamp technique;
potassium channel
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To Investigate the effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig. METHOD Using whole cell patch clamp technique. RESULTS Breviscapine enhanced I k dose dependently. Breviscapine with the concentration of 0\^01 and 0\^02 mg?L -1 increased I k by 44.6% and 78.3%,respectively. The effect could be reversed by washing. CONCLUSION Breviscapine can open the K + channel and incrase I k .
