Antigen presenting action and MHC limitation of Kupffer cells in immune response of halothane hepatitis
- VernacularTitle:氟烷性肝炎免疫应答中Kupffer细胞的抗原递呈作用和MHC限制
- Author:
Zhijie LU
;
Weifeng YU
;
Weimin SUN
;
Zhenmeng WANG
;
- Publication Type:Journal Article
- Keywords:
halothane;
hepatitis,toxic;
Kupffer cells
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the antigen presenting of Kupffer cells in immune response of Guinea pig halothane hepatitis. Methods:Sixteen male Guinea pigs were randomly divided into 2 groups. Experimental group:1% halothane and 40% O 2 were inhaled for 4 h, re inhaled on the 42nd and 84th day; Control group:only inhaled 40% O 2. Lymphocytes and Kupffer cells were separated and the culture was mixed on the 21st day after the last inhalation. 3H TdR was added 18 h before the end of culture. Immune response and the antigen presenting action of Kupffer cells were analysis by lymphocyte transformation test (LTT). Results:Halothane had significant pro proliferative effects on autologous lymphocytes( P
