Change of plasma cyclic nucleotide in patients of rheumatic heart disease with pulmonary hypertension
- VernacularTitle:风湿性心脏病肺动脉高压患者肺动脉血浆环核苷酸水平的变化
- Author:
Jianghong YE
;
Meifang YAO
;
Jialin ZHU
;
Meiying XU
;
Zhengkang FENG
;
- Publication Type:Journal Article
- Keywords:
rheumatic heart disease;
hypertension, pulmonary;
cyclic GMP;
cyclic AMP;
hemodynamics
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the change of plasma cyclic nucleotide in patients of rheumatic heart disease with pulmonary hypertension and to evaluate the relationship between plasma cyclic nucleotides and hemodynamics. Methods:Plasma cGMP and cAMP were examined by radioimmunoassay, hemodynamic data were obtained with Swan Ganz catheter and the HP compact configurable monitors. Results:Plasma cyclic nucleotide increased in patients of rheumatic heart disease with pulmonary hypertension and had an obvious correlation with the level of PAPM, PVR, PAWP and CI. Conclusion:Increased cAMP and cGMP is one of the pathophysiological characters of pulmonary hypertension, cAMP and cGMP, as the second messenger, may play an important regulating role in the development of pulmonary hypertension.
