Biological assessment of sustained-release bistratal drug-film of dexamethasoni acetate
- VernacularTitle:醋酸地塞米松双层缓释贴膜的生物安全性评价
- Author:
Guoqin LIU
;
Xiaopeng MA
;
Peizhi SONG
;
Haiying LIU
;
Huimin HOU
;
Fen HE
;
- Publication Type:Journal Article
- Keywords:
dexamethasone;
delayed action preparations;
drug film;
biological safety;
toxicity
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the biological safety of the sustained release bistratal drug film of dexamethasoni acetate (DA). Methods:A series of tests, including acute toxicity test, cytotoxity test (agar overlay), oral mucous membrane irritation test and haemolysis test were conducted. Results:Cytotoxic effect was not observed, nor was toxic effect in mouse toxicity test. The haemolysis rate of this material was 0.46%. Local mucous membrane irritation reaction was not found. Conclusion:The drug film of DA shows excellent biocompatibility on the preliminary tests.
