Inhibition of resveratral on lipid peroxidative reaction and reactive oxygen species of early experimental rat spinal cord injury
- VernacularTitle:白藜芦醇对急性脊髓损伤早期脂质过氧化反应和活性氧水平的抑制作用
- Author:
Yingbao YANG
;
Yingjie PIAO
;
- Publication Type:Journal Article
- Keywords:
resveratrol;
spinal cord injury(SCI);
superoxide dismutase(SOD);
malondialdehyde (MDA);
reactive oxygen species(ROS)
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of resveratral on lipid peroxidative reaction and reactive oxygen species (ROS) in experimental spinal cord injury rats. METHODS: The weight dropping method was used to produce the experimental spinal cord injury (SCI) in adult rats. Resveratrol (Res) and methylprednisolone (MPSS) were given intraperitoneally by the bolus injections of 50, 100 mg?kg -1 and 100 mg?kg -1 , respectively, immediately after induction of SCI. And then the effects of Res were observed at 1, 24, 48 h after SCI compared with MPSS. RESULTS: Res could obvious prevented reduction of superoxide dismutase (SOD) activity and reduce malondialdehyde (MDA) production and inhibit the ROS level in the injured spinal cord tissue in comparison with the SCI model at the dose of 50 mg?kg -1 and 100 mg?kg -1 , which the most remarkable effects was at 48 h with the inhibition rate over 40%. The effects of Res were the same as or even greater than those of MPSS. CONCLUSION: Res may effectively protect the spinal cord from lipid peroxidative reaction and ROS damage in SCI.
