Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits
- VernacularTitle:茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用(英文)
- Author:
Zongyuan HONG
;
Qingshan ZHENG
;
Changqing GUI
;
Jianguo SONG
;
Ruiyuan SUN
;
- Publication Type:Journal Article
- Keywords:
tea polyphenols;
C BSA glomerulonephritis;
rabbit;
animal model
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the therapeutic effect of tea polyphenols (TP) on cationic bovine serum albumin (C BSA) glomerulonephritis. METHODS: C BSA glomerulonephritic model was induced in rabbits. TP in three different doses (30, 100 and 300 mg?kg -1 ) was administered (ig) once daily for 14 days. RESULTS: TP not only significantly reduced the urinary protein excretion, decreased blood urea nitrogen (BUN) and plasma creatinine (Cr) levels, but also significantly relieved gloermular lesions in the rabbits treated and there was a significant dose dependent relationship between high dosage (300 mg?kg -1 ) and low dosage ( 30 mg?kg -1 ). CONCLUSION: TP can reduce proteinuria, suppress the development of glomerular impairments, and ameliorate the kidney function of rabbits with C BSA glomerulonephritis.
