Pharmacogenomics and selection of antihypertensive drugs
- VernacularTitle:药物基因组学与高血压病的药物选择
- Author:
Xia TAO
;
Gaolin LIU
;
- Publication Type:Journal Article
- Keywords:
pharmacogenomics;
hypertension;
individualized drug therapy;
genetic polymorphism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacogenomics is defined as the study of the association between genetics and drug response. This review includes basic concepts of pharmacogenomics, heterogeneity of hypertension and antihypertensive drug responses, genes associate with drug metabolism, and individualized drug therapy. The knowledge of genes that influence the pharmacodynamic determinants of blood pressure response to antihypertensive medications has the potential to provide new insights not only into molecular mechanisms influencing drug response, but also into the role that these genes may play in determining interindividual differences in blood pressure level and the occurrence of hypertension.
