Advances of pharmacokinetic studies of topiramate,a new antiepileptic agent
- VernacularTitle:抗癫痫新药托吡酯药代动力学研究现状
- Author:
Ximei HE
;
Xin HE
;
Erhuai ZHANG
;
- Publication Type:Journal Article
- Keywords:
topiramate;
epilepsy;
pharmacokinetics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The article introduced advances of pharmacokinetic studies of topiramate, a new antiepileptic agent, in recent years. Topiramate pharmacokinetic parameters were determined after the administrations of single dose, multiple dose and concomitant therapy. The changes of its pharmacokinetic parameters were determined in the influence of the factors, for example, age, disease, and so on. These results have revealed the regulations of metabolism and excretion of topiramate in the healthy volunteers and patients. The data provide a basis of clinical rational medication for the patiens with epilepsy.
