Binding capacity of 5-HT_(1A) receptor in central nervous system and hypertension in rats
- VernacularTitle:大鼠中枢5-HT_(1A)受体的结合容量与高血压
- Author:
Jing ZHOU
;
Zhongjin TANG
;
Yuansheng LIU
;
Dingfeng SU
;
Gaolin LIU
;
- Publication Type:Journal Article
- Keywords:
receptors,serotonin;
hypertension;
radioligand assay
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
40 weeks old SHR did not differ from that in slices of age matched WKY. B max was increased in the same brain region of SHR when compared to WKY. That rats of 4 5 weeks were in prehypertensive stage;rats of 10 12 weeks and above were at the stage of establishing hypertensive stage. Conclusion: The difference between SHR and normotensive rats in 5 HT 1A receptor binding in various brain regions may be related to the development of hypertension. When blood pressure changes,binding capacity of 5 HT 1A receptor in CNS changes accordingly.
