Effects of cocaine on the development of fetal nerve system
- VernacularTitle:妊娠中晚期接触可卡因对小鼠胎儿神经系统发育的影响
- Author:
Jun SONG
;
Xiaowei GUAN
;
Wei HE
;
Jiaqian REN
;
- Publication Type:Journal Article
- Keywords:
cocaine;
pregnant mouse;
fetus;
nerve system;
neurotransmitter;
development;
malnutrition
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To develop a murine model for investigating the effects of prenatal cocaine exposure on the development of fetal nerve system. METHODS A nutritionally paired control group of dams injected with saline and pair fed with the COC dams were set up. Another two groups were COC groups injected with cocaine HCl and SAL group administrated with saline. After injection twice daily during gestation days 8～17,mice were decapitated on E17 and blood and brain samples were collected for pharmacological analysis and neurotransmitter analysis by HPLC.RESULTS Pharmacological analysis revealed that cocaine was found in maternal and fetal plasma at 15 min following ip administration to embryonic day E17 pregnant mice. Though COC dams and SPF dams had the same feeding condition, compared with the latter, the former had higher maternal concentrations of DA and 5 HT, lower fetal weight, brain weight, striatum weight and higher concentrations of DA and 5 HT in striatum, P
