Protective effects of baicalin on myocardial injury induced by ischemia and reperfusion in rats
- VernacularTitle:黄芩苷对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Hua LIU
;
Xiaodong WU
;
Honglan WANG
;
Yan YIN
;
Guangyuan HE
;
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
myocardial reperfusion injury;
baicalin;
hemodynamics;
lipid peroxidation;
malondialdehyde;
lactate dehydrogenase
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective and antiperoxidative effects of baicalin on myocardial ischemia. METHODS The rat anterior decenging branch of left coronary artery was occluded for 40 min and reperfusion for 120 min. Hemodynamics (LVP, LV d p /d t ) and electrocardiogram (ECG, lead Ⅱ) monitored continuously with polygraph,then the myocardium were taken to assay lactate dehydrogenase(LDH), malondialdehyde (MDA) contents and superoxide dismatase (SOD). RESULTS Baicalin 10 or 40 mg?kg -1 iv depressed changes in LDH, MDA and SOD in myocardium after ischemia for 40 min and reperfusion for 120 min in rats. Baicalin 10 and 40 mg?kg -1 iv markedly improved the ?d p /d t max (kPa?s -1 ), LVSP in rat after ischemia for 40 min and reperfusion. CONCLUSION Baicalin possesses a protective effect against myocardial ischemia via attenuating lipid peroxidation.
