Effects of different interval intracerebroventricular administration of brain-derived neurotrophic factor on hypoxic ischemic encephalopathy in neonatal rats
- VernacularTitle:不同时间脑室注射脑源性神经营养因子治疗新生大鼠缺氧缺血性脑损伤效果的比较
- Author:
Xinru HONG
;
Xinmin CHEN
;
Xiaoxin LU
;
- Publication Type:Journal Article
- Keywords:
brain derived neurotrophic factor;
brain hypoxia;
brain ischemia;
rat, newborn
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of different interval administration of exogenous brain derived neurotrophic factor (BDNF) on hypoxic ischemic encephalopathy in neonatal rats. METHODS BDNF (0 5 ?g) was microinjected intracerebroventricularly at 0, 1 and 4 h after the hypoxic ischemic encephal opathy in 7 d neonatal Sprague Dawley rats undergone by ligation of left common carotid artery followed by a 2 5 h inhalation of humidified 8% O 2+92% N 2 at 37℃ immediately after the injury, respectively. Changes of brain edema, levels of malondialehyde (MDA) and neuronal apoptosis at the left cortex and hippocampus were investigated 24 h after the injury. RESULTS The most prominent effect of BDNF was seen in 0 h group with a marked decreases in brain edema and levels of MDA and a significantly alleviated neuronal apoptosis while it was lowered obviously when administered at 4 h after the insult. CONCLUSION BDNF exerts a prominent protective effect on hypoxic ischemic encephalopathy in neonatal rats when given as early as possible after the injury rather than later administration.
