Experimental study of the anti-atherogenesis effects of sodium ferulate in hyperlipidemia rabbit and its mechanisms
- VernacularTitle:阿魏酸钠对高脂血症家兔动脉粥样硬化形成的影响及其机制的研究
- Author:
Jingping OUYANG
;
Baohua WANG
;
Yongming LIU
;
Jingwei YANG
;
Lei WEI
;
Ke LI
;
- Publication Type:Journal Article
- Keywords:
sodium ferulate;
NO;
TGF? 1;
bFGF;
atherosclerosis
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the anti atherogenesis action of sodium ferulate and its mechanisms. METHODS Atherosclerotic rabbit models were duplicated by feeding high lipid forage and ECV304 were cultured with the hyperlipidemic serum. The atherosclerotic plaque area was measured. Scanning electron microscope, spectrophotometer and immunocytochemical methods were used to detected the microstructures of endothelial cell, the content of NO in suspension and the expressions of TGF? 1, bFGF on the cell surfaces. RESULTS Sodium ferulate could decrease the plaque area, lessen the damnification of endothelial cell induced by HLS, enhance the expression of TGF? 1 and the release of NO from ECs, and reduce the expressions of bFGF in ECs, significantly. CONCLUSION Sodium ferulate can decrease the atherosclerotic plaque area induced by hypercholesterol, which may be relate to the expression change of cytokines.
