Effect of L-NNA on GFAP production in the gerbil hippocampus after recirculation following ischemia
- VernacularTitle:免疫荧光法检测L-NNA对脑缺血再灌流后海马区GFAP合成的影响
- Author:
Jingjun ZHANG
;
Qing CHEN
;
Zuoli XIA
;
- Publication Type:Journal Article
- Keywords:
NG nitro L arginine;
cerebral ischemia;
hippocampus;
glial fibrillary acidic protein
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of L NNA on glial fibrillary acidic protein (GFAP) production in the gerbil hippocampus after recirculation following ischemia. METHODS Both vessels occlusion and immunofluorescent methods in gerbil hippocampal tissue slices incubated in vitro were used. RESULTS Recirculation following ischemia led to a rise on GFAP concentration in the hippocampus. GFAP positive cells mainly distributed in rediatum layer and molecullar layer in the hippocampus, L NNA decreased GFAP synthesis. CONCLUSION L NNA is a strong inhibitor of nitric oxide synthase(NOS). It is possible that the role of endogenous NO mediated GFAP synthesis is inhibited by L NNA.
