Effect of hyperbaric oxygen on apoptosis in CA_1 pyramidal cell layer of gerbil hippocampus following forebrain ischemia reperfusion injury
- VernacularTitle:高压氧治疗对沙土鼠脑缺血再灌注海马CA_1区神经元凋亡的影响
- Author:
Jianguang ZHOU
;
Yali HUANG
;
Changyun LIU
;
Haifeng ZHANG
;
Jingchang LIU
;
- Publication Type:Journal Article
- Keywords:
hyperbaric oxygen;
cerebral ischemia;
reperfusion injury;
hippocampus;
neurons;
apoptosis
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the changes of neuronal apoptosis induced by ischemia reperfusion in gerbil hippocampus CA 1 after hyperbaric oxygen(HBO) treatment, and to study the effects of HBO on the treatment of cerebral ischemia. Methods: Ischemia reperfusion model of gerbil was established. The effects of HBO treatment for 3 succesive days on neuronal apoptosis of hippocampus CA 1 were examined using H E and TUNEL staining methods. Results: The number of neuronal apoptosis in hippocampus CA 1 was significantly decreased in HBO treatment groups ( P
