Effect of metronidazole on percutaneous absorption of l-menthol through changing the skin character in rabbits
- VernacularTitle:皮肤性状改变后薄荷醇对甲硝唑透皮吸收作用的影响
- Author:
Weiming XU
;
Hui WANG
;
Xiaolong FENG
;
- Publication Type:Journal Article
- Keywords:
l menthol;
metronidazole;
percutaneous absorption;
permeability;
deposit function
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of l menthol on percutaneous absorption of metronidazole through changing the skin character in rabbits. METHODS: Using rabbit skin with different character as transdermal barrier, and l menthol as transdermal enhancer, the absorbance of metronidazole was determined with a two cells diffusion apparatus in vitro, and its permeability was figured out. RESULTS: The transdermal action of l menthol on percutaneous absorption of metronidazole was very evident when the corneum was eliminated; l menthol and azone could increase the desposit function of metronidazole in the intact skin, but had no effect on the skin without corneum. The result also showed that the percutaneous absorption and intact skins desposit function of metronidazole had no difference between l menthol and azone. CONCLUSION: L menthol can increase the percutaneous absorption of metronidazole. The site of the action is mainly the corneum which has desposit function.
