Effect of clarithromycin on pharmacokinetics of aminophylline at steady state in rabbits
- VernacularTitle:克拉霉素对兔体内稳态时氨茶碱药代动力学的影响
- Author:
Chengchun SUN
;
Xiaoyuan ZHAO
;
Yang CAO
;
Jingxiang WANG
;
- Publication Type:Journal Article
- Keywords:
aminophylline;
clarithromycin;
blood concentration;
pharmacokinetics parameter
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of oral clarithromycin on serum concentrations of aminophylline at steady state and its pharmacokinetics in New Zealand rabbits. METHODS: The serum concentration of aminophylline was determined by FPIA in rabbits given(po) aminophylline or aminophylline combined with clarithomycin. The experiment was divided into 2 stages: (Ⅰ)the subjects only received a four day course of oral aminophylline until steady state;(Ⅱ)aminophylline and clarithromycin were coadministrated from the d 5 to d 10. The dose of aminophylline was 30 mg?kg -1 and the dose of clarithromycin was 50 mg?kg -1 for each rabbit. The two series of pharmacokineticis parameters were tested by statistic analysis. RESAULTS: There was no significant variation in pharmacokinetic parameters between two stages. CONCLUSION: It is not necessary to change the therapeutic dose of aminophylline when the drug is taken in combination with clarithromycin.
