Protective effects of amitriptyline on glutamate-induced neurotoxicity in cerebral neuronal cultures
- VernacularTitle:阿米替林对谷氨酸损伤中枢神经细胞的保护作用
- Author:
Qingrong XU
;
- Publication Type:Journal Article
- Keywords:
amitriptyline;
glutamate;
cerebral cortical neurons;
cell culture
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of amitriptyline (Ami) on glutamate induced neurotoxicity in cultured rat cerebral cortical neurons. METHODS: Cortical neurons of fetal rat were cultured in vitro. The protective effects of Ami on glutamate induced neurotoxicity were observed. RESULTS: Exposure of rat fetus cerebral cells to Glu medium developed a neurotoxicity, expressed in the increase of LDH, NO and MDA, and the decrease of activity of SOD,as well as the development of morphological injury. Ami (10 -6 ,10 -7 , 10 -8 mol?L -1 ) significantly protected neurons against above demage. CONCLUSION: Ami can prevent rat cerebral neurons injury from the toxicity of Glu.
