Comparison of the effect of azone and menthol on the percutaneous absorption of indomethacin in vitro
- VernacularTitle:薄荷醇和氮酮对吲哚美辛体外促透作用的比较
- Author:
Zhenzhong ZHA
;
Hui WANG
;
Xiaolong FENG
;
Weiming XU
;
- Publication Type:Journal Article
- Keywords:
menthol;
azone;
indomethacin;
percutaneous absorption
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the permeation enhancing characters of menthol and azone on the model drug of indomethacin and to study the enhancing effect when the two agents were used in combination. METHODS: The transdermal test was conduced on the penetration experiment apparatus of isolated skin. The cumulate penetrated amount, penetrating rate, stable flux and lag time were calculated upon the concentrations. RESULTS: After adding the penetration enhancer, the penetrating rate of indomethacin increased remarkably. It was 6.21 , 4.91 and 6.92 times of that of the controls respectively. When used in combination, the two penetration enhancers increased much more the penetrating rate than being used separately (P
