The effects and the mechanisms of exogenous fatty acids on colorectal cancer cells
- VernacularTitle:外源性脂肪酸对结肠癌细胞生长的影响及其可能机制
- Author:
Wenwei CAI
;
Tianfang HUA
;
Jun CAO
;
Qing GU
;
Dun SHI
;
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Fatty acid;
Ployunsaturated fatty acids;
Malonaldehyde(MDA)
- From:
Parenteral & Enteral Nutrition
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To observe the effects and the mechanisms of exogenous fatty acids on colorectal cancer cells(LoVo). Methods:The effect of exogenous fatty acids on LoVo cells was determined by 5 diphenyl tetrazolium bromide(MTT) assay.The content of MDA was examined to evaluate the extent of lipid peroxidation. Results:The growth of LoVo cells was inhibited by polyunsaturated fatty acids(PUFAs).The inhibitory effect of saturated fatty acids and monounsaturated fatty acids on LoVo cells was not showed.None of the fatty acids was found to fibroblast cells(HLF).PUFAs caused the significant rising of intracellular MDA content. Conclusions:PUFAs could inhibit the growth of colorectal cancer cells.The strengthening of lipid peroxidation may be one of the mechanisms.
