Immunohistochemical study on the expression of IL-6, IL-8 and TNF-? in gunshot wounds in soft tissues
- VernacularTitle:枪弹伤口软组织中IL-6、IL-8、TNF-?变化的免疫组化研究
- Author:
Yang WU
;
Shuxia ZHOU
;
Lin MIAO
;
Xiujuan LI
;
- Publication Type:Journal Article
- Keywords:
interleukin 6;
interleukin 8;
tumor necrosis factor;
wound,gunshot;
mandibular injuries
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between interleukin(IL) 6, IL 8, tumor necrosis factor alpha (TNF ?) and wound healing. Methods: In lower jaw gunshot wound, the expression of IL 6, IL 8, TNF ? in local soft tissues was assayed by using immunohistochemistry methods. The current levels of IL 6, IL 8, TNF ? in wound tissues was analysed by using image assay. Results: High expressions of these cytokines were observed in local soft tissues of wounds during the first 3 d after the gunshot. The cytokines expressions were different between the area near the bullet path and that far from the path. There was only one peak of the cytokines concentration in the area far from the bullet path, while there were 2 peaks of the cytokines concentration in the area near the bullet path.Conclusion: These results suggest that IL 6, IL 8, TNF ? play an important role in regulating inflammatory reactions of local injured tissues. They may improve the functions of fibroblasts, mononuclear phagocytes and endothelial cells and stimulate wound cells to produce and release other cytokines.
