Effects of extraneous rh-TNF-? on wound healing
- VernacularTitle:外源性rh-TNF-?局部介入对创伤愈合的影响
- Author:
Yang WU
;
Shuxia ZHOU
;
Xiujuan LI
;
Lin MIAO
;
- Publication Type:Journal Article
- Keywords:
wound and injuries;
tumor necrosis factor
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of TNF ? on wound healing. Methods: The skin lesion and incisions were made on mice and rh TNF ? was applied in both skin lesion and incision. Tissue strips were evaluated for tensiometry and histologic features after healing. Results: It was found that rh TNF ? markedly improved wound healing both in skin lesion and incision wound model, it also markedly enhanced the breaking strength of treated incision and increased wound cellularity in rh TNF ? treated groups. Conclusion: The results suggest that TNF ? play an important role in regulating inflammatory reactions of local injured tissues and it may improve the functions of fibroblasts, mononuclear phagocytes and endothelial cells. rh TNF ? of suitable doses can promote wound healing. This shows that TNF ?, as a wound healing promoter, has the potentials for clinical application.
