Study on melatonin nasal absorption
- VernacularTitle:褪黑素鼻粘膜吸收规律的研究
- Author:
Jianming CHEN
;
Shen GAO
;
Lika YE
;
Shirui MAO
;
Dianzhou BI
;
- Publication Type:Journal Article
- Keywords:
melatonin;
nasal mucosa;
absorption;
in situ rat nasal recirculation method
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the rule of melatonin nasal absorption.Methods: The stability of melatonin in rat nasal wash was studied, after that the in situ rat nasal recirculation methods were used as experimental animal model to study the rule of melatonin nasal absorption.Results:Melatonin was stable in rat nasal wash, its absorption in nasal cavity accorded with first order kinetic equation. The absorption rate constants did not vary with melatonin concentrations.Conclusion:The mechanism of melatonin nasal absorption is passive diffusion, the average absorption rate constant is 1.054?10 -2 min -1 .
