Effect of estrogen replacement therapy on chemokine receptor CXCR2 in monocytes in postmenopausal women with coronary artery disease
- VernacularTitle:冠心病妇女绝经后雌激素替代治疗对趋化因子受体 CXCR2的影响
- Author:
Zhubin LEI
;
Jianping LIU
;
Min WEI
;
Jingbin DOU
;
- Publication Type:Journal Article
- Keywords:
estrogens;
receptors,chemotactic factors;
coronary disease;
menopause
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the change of chemokine receptor CXCR2 in monocytes in postmenopausal women with coronary artery disease (CAD) after estrogen replacement therapy. Methods: Randomized placebo controlled trial was conducted in 22 post menopausal women with CAD and 20 normal menopausal women by giving 0.625 mg premarin daily or vitamin C treatment for 3 months. Serum estradiol (E 2) and chemokine receptor CXCR2 in peripheral blood monocytes were measured at 0 and 3 months of treatment. Results:(1) E 2 and CXCR2 levels in the CAD group was lower than that in the normal group ( P
