11?-hydroxysteroid dehydrogenase and hypertention
- VernacularTitle:11?-羟化类固醇脱氢酶与高血压
- Author:
Bing YAO
;
Yindi ZHANG
;
- Publication Type:Journal Article
- Keywords:
hydroxysteroid dehydrogenase;
apparent mineralocorticoid excess;
hypertention
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
hydroxysteroid dehydrogenase (11? HSD) catalyzes the interconversion of cortisol with its inactive metabolite cortisone. The congenital deficiency of 11? HSD2 induce hypertension and hypokalemia. This disorder is called "Apparent Mineralocorticoid Excess(AME)". Glycyrrhizic acid and other endo and xenobiotics have been found to inhibit the activity of 11? HSD and cause excess mineralocorticoid effects that is similar to AME. The decrease in 11? HSD activity is related with the acquired and congenital hypertention.
