Recombinant in vitro tools to predict drug metabolism and safety
- VernacularTitle:CYP450s体外重组技术及在药物代谢和安全性评价中的应用
- Author:
Haixue WANG
;
Qiaolin DENG
;
Duan LI
;
- Publication Type:Journal Article
- Keywords:
recombinant;
CYP450;
in vitro;
drug metabolism;
safety
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalyzed by drug metabolizing enzymes. Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetical properties of candidate drugs in humans.
