Effect of clonidine on intraocular pressure and its central adrenergic mechanism
- VernacularTitle:可乐定降低眼内压的中枢肾上腺素能机制
- Author:
Xiaoou ZHOU
;
Guangdi YU
;
Shiyu GUO
;
- Publication Type:Journal Article
- Keywords:
intraocular pressure;
clonidine;
yohimbine;
prazosin;
locus coeruleus;
? 2 adrenoceptor
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of clonidine on intraocular pressure(IOP) and the possible role in which ? adrenergic mechanism plays. METHODS The change on IOP was observed following clonidine administered via three different routes: (1)clonidine topically administered to eyes; (2)clonidine intracerebroventricularly injected (icv)or topically administered after yohimbine or prazosin icv; (3)microinjection of clonidine into locus coeruleus(LC). RESULTS Clonidine decreased IOP significantly, ? 2 adrenoceptor antagonist, but not ? 1 adrenoceptor antagonist, can reverse the decreasing effect on IOP caused by clonidine icv and administered topically. CONCLUSION Clonidine administered both topically or intracranially can decrease IOP;? 2 adrenoceptor in central nervous system is involved in this effect.
