Effect of methionine-enkephalin on proliferation and mechanism involved by opiate receptor of peripheral blood lymphocyte from patients with systemic lupus erythematosus
- VernacularTitle:甲硫氨酸脑啡肽对系统性红斑狼疮患者外周血淋巴细胞增殖反应的影响及阿片受体介导机制的研究
- Author:
Xingming XU
;
Hong DAI
;
Xiaohua WANG
;
Wei WEI
;
- Publication Type:Journal Article
- Keywords:
methionine enkephalin;
systemic lupus erythematosus;
peripheral blood lymphocyte;
opiate receptor
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM\ To observe the effect of methionine enkephalin(Met Enk) on proliferation and mechanism involved by opiate receptor of peripheral blood lymphocyte(PBL) from patients with systemic lupus erythematosus(SLE). METHODS\ Lymphocyte proliferation assay. RESULTS\ Naloxone (Nal,1?10 -6 mol?L -1 )could block the increasing effect of Met Enk(1?10 -8 ～1?10 -6 mol?L -1 )on the PBL proliferation of normal humans,but there was no direct effect on that. However,Nal could not only block the promotive action of Met Enk on PBL proliferation of SLE patients,but there was a direct decreasing effect on it. CONCLUSION\ Endogenous Met Enk may participate in the abnormal regulation with SLE PBL via opiate receptor.
