Reactivative effect of neferine on the poisoning mice of cholinesterase with organophosphate
- VernacularTitle:甲基莲心碱对有机磷中毒小鼠胆碱酯酶的重活化作用
- Author:
Yuqing XIONG
;
Fandian ZENG
;
- Publication Type:Journal Article
- Keywords:
neferine;
organophosphate;
cholinesterase;
reactivation
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the reativative and protective effect of Neferine (Nef) on the poisoning mice of cholinesterase (ChE) with dichlorves (DDVP) or dipterex (Dip) of LD 100 . METHODS The mice were randomly divided into poisoning group with DDVP or Dip and Nef, Atropine and Pyraloxime methylchloride (PAM Cl) treatment group. Activity of mice blood ChE was determined with Ellmaris method, and acute toxicity experiment was used to determine the protective effect. RESULTS ① Nef (15 mg?kg -1 , ip) exhibited a definite protective effect on poisoning mice, and the mortality of the animals treated with Nef was significantly lower than that of the control group with normal saline ( P 0 05). But Nef and atropine group was significantly lower than that of thePAM Cl group ( P
