Protective effects of procyanidins' extract from the lotus' seedpod on experimental myocadial injury in rat
- VernacularTitle:莲房原花青素对大鼠实验性心肌缺血的保护作用
- Author:
Zhiqun LING
;
Bijun XIE
;
Tao JIANG
;
Fandian ZENG
;
- Publication Type:Journal Article
- Keywords:
LSPC;
myocardial ischamia;
isoproternol
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of procyanidins' extract from the lotus' seedpod(LSPC) on experimental myocardia injury in rats. METHODS Compared with diltiazem(10 mg?kg -1 ?d -1 ) and complex salvia (8 mg?kg -1 ?d -1 ), after one hour supplementation of LSPC, the model of myocardial injury induced by subcutaneous injection of isoproterenol (40 mg?kg -1 , twice )and by cardiac ischemia in situ were studied with rat hearts. RESULTS LSPC pretreatment (100 and 200 mg?kg -1 ) significantly antagonized the high serum of CK,CK MB,LDH, calcium and the high content of myocardial water, calcium, provided significant reduction in myocardial infarct size, increased the ratio between superoxide dismutase activity and malondialdehyde production in serum, lighted the degree of myocardial pathological damage. CONCLUSION LSPC provided a protection on ischemic myocardium in rats and the action is considered to be related to the inhibition of lipid peroxidation or myocardial Ca 2+ accumulation.
