Effects of total paeony glycoside on learning and memory capacity and related substances of senile Mice induced by D-galactose
- VernacularTitle:赤芍总苷对D-半乳糖衰老小鼠学习记忆及代谢产物的影响
- Author:
Jun YANG
;
Jing WANG
;
Wen JIANG
;
Chuangeng MA
;
Shuyun XU
;
- Publication Type:Journal Article
- Keywords:
total paeony glycoside;
senility;
learning and memory;
spatial resolution;
cholinesterase;
monoamine oxidase;
superoxide dismutase;
malondialdehyde
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate actions of total paeony glycoside(TPG) on learning and memory capacity and related products of metabolism of senile mice induced by D galactose. METHODS The subacute senile mouse models induced by injection of D galactose subcutaneously were used. RESULTS TPG could improve the learning and memory capacity of model mice in shuttle test and enhance spatial resolution in water maze test. TPG not only reduced the content of monoamine oxidase(MAO) and inhibited the decrease of cholinesterase(CHE) significantly, but also lessened the level of malondialdehyde(MDA) and inhibited the decrease of superoxide dismutase(SOD) in cerebrum of model mice. TPG still promoted the recovery of lobar atrophy and hypoimmunity of senile mice remarkedly. CONCLUSION TPG possesses obvious effects of improvement on learning, spatial resolution and delaying senility.
