Early mechanism of action of arterially infused ethanol: an experimental study on the influence of infusionspeed.
10.3348/jkrs.1988.24.6.933
- Author:
Joon Koo HAN
- Publication Type:Original Article
- MeSH:
Aorta;
Aortography;
Arteries;
Endothelium;
Erythrocytes;
Ethanol*;
Kidney;
Perfusion;
Phenobarbital;
Thrombosis
- From:Journal of the Korean Radiological Society
1988;24(6):933-941
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Abdonimal aortography and histopathologic examinatio after absolute ethanol infusion at ast (0.4cc/sec) andslow speed (0.04cc/sec) were performed on 16 rats(2 controls, 7 fast infusion groaup, 7 slow infusion group).Angiographic and histopathologic findings were correlated and the findings of slow and fast infusion groups werestudied. The rsults are as follows: 1.Histopathologic findings of the fast infusion group revealed wide area ofglomerular and tubular collapes, obliteration of the free space between the Bowmann's capsule and golmerulus,sloughing and loss of the endothelium, fresh thormbi attached to the wall, and cleavage of the muscle layer of thearteries. 2. Angiographic findings of the fast infusion group revealed luminal irregularity, early ostruction ofthe aorta and the renal arteries,and delayed circulation time. 3. Histopathologic findings of the slow infusiongroup revealed degenerated, coalesced red blood cell packed in the glomeruli, focal areas of severe glomerular andtubular damage on relatively normal backgroun, endothelial and muscular damage of the arteries. 4. Angiographicfindings of the slow infusion group revealed focal perfusion defect of the kidney, delayed circulation time, andmild luminal irregularity, but there was no obstruction of the major arteries. 5. In conclusion, author believesthat endothelial damage and thrombus formation from the damaged vessel wall, as well as direct cytotoxicity and insitu emboli fommation play a significant role in the embolic effect of absolute ethanol.
