Alteration of bone matrix components in degenerative vertebra metabolism of cervical spondylosis
- VernacularTitle:骨基质成分在退变颈椎骨代谢中的变化
- Author:
Yaojun XIANG
;
Hongxing SHEN
;
Qian SHEN
;
Kai ZHOU
;
Jiashun LI
;
Tiesheng HOU
;
Lianshun JIA
;
- Publication Type:Journal Article
- Keywords:
cervical spondylosis;
bone matrix
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the biological mechanism of the degeneration of cervical spine in cervical spondylosis(CS) by analyzing the alteration of bone matrix components.Methods:Twenty five degenerative cervical vertebra and 8 blood samples from CS cases were collected.The contents of hyaluronic acid(HA),laminin(LN),pro collagen Ⅲ,collagen Ⅳ were detected by radioimmunoassay.Calcium,phosphate and total protein levels were detected by automatic biochemical analyzer.Results:Ruling out the inference of blood, the contents of HA, LN, pro collagen Ⅲ and collagen Ⅳ were significantly lower in degenerated CS vertebra than in the control, so as the levels of calcium and phosphate. Conclusion:Bone matrix components are obviously decreased during the degeneration of cervical vertebra, resulting in the alleviation of bone tenacity and hardness. This may be one of the biological mechanisms of cervical vertebra degeneration and deterioration of cervical spine biomechanics.
