The possible role of phospholipase A_2 in low back and leg pain
- VernacularTitle:磷脂酶A_2在腰腿痛发病中的可能作用
- Author:
Shisheng HE
;
Tiesheng HOU
;
Yi CUI
;
Jianwen WANG
;
Jinhui XIA
;
Jie WANG
;
- Publication Type:Journal Article
- Keywords:
intervertebral disk displacement;
phospholipases A;
substance P;
cauda equina
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the role of phospholipase A 2 in the pathomechanism of low back and leg pain. Methods:Phospholipase A 2 was injected into rats′ cavum epidurale, then the pathologic changes of cauda equina was viewed under light microscopy and electronic microscopy. The substance P(SP) in the dorsal root ganglia(DRG) and spinal cord was determined by immunohistochemistry. Results:After phospholipase A 2 injection, the nerve fibers of cauda equina displayed significant degeneration and demyelination. In L 4 to L 6 segment, the number and area of SP positive neurons in the DRG increased significantly. The relative density of positive nerve endings in the dorsal horn of spinal cord was also increased significantly. There were significant difference compared to the normal solution control group by statistic analysis. Conclusion:Phospholipase A 2 is a nocuous substance to cauda equina. It may play an important role in the pathomechanisms of low back and leg pain related to lumbar disc herniation.
