Effect of N-n-butyl haloperidol iodide on potassium channel in smooth muscle cells and rings of rat aorta
- VernacularTitle:碘化N-正丁基氟哌啶醇对大鼠胸主动脉平滑肌钾通道作用的研究
- Author:
Risheng WEI
;
Ganggang SHI
;
- Publication Type:Journal Article
- Keywords:
N n butyl haloperidol iodide;
vascular smooth muscle cells;
enzymatically dispersed;
whole cell patch clamp technique;
potassium currents;
aortic rings;
glibenclamide
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of N n butyl haloperidol iodide (F 2) on potassium currents in enzymatically isolated vascular smooth muscle cells (VSMC) from thoracic aortas and the effect of F 2 on aortic rings of rat. METHODS The whole cell patch clamp technique and the contraction of rats thoracic aortic rings were used in experiments. RESULTS The outward currents were observed when holding potential was -40 mV and the cell was depolarized from -30 mV to +100 mV (in 10 mV increase) for 400 ms. At the point of the test potential of +70 mV, solutions of F 2 (0 1,1, 5 ?mol?L -1 ) were added into bath (external) solution, which led to the increase of the outward currents from (229?28)pA,(226?57)pA and(228?42) pA to (354?29) pA ( n =6, P
