Effect of procyanidins on the release of H_2O_2 induced by croton oil and on lipid peroxidation
- VernacularTitle:原花青素抗促癌物诱发H_2O_2释放及脂质过氧化
- Author:
Yin LU
;
Zhiguang SUN
;
Wanzhou ZHAO
;
Junshan RUAN
;
Xinqi YAN
;
- Publication Type:Journal Article
- Keywords:
procyanidins;
vitis vinifera;
anti oxidation;
polymorphonuclear leukocytes;
mitochondria
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the anti oxidation and cancer chemoprevention mechanism of procyanidins extracted from Vitis vinifera. METHODS A simple colorimetric method is used for the measurement of H 2O 2 produced by PMNs induced by croton oil. RESULTS It was shown that procyanidins could inhibit PMNs releasing H 2O 2 induced by croton oil. Procyanidins serum of rats also had the same effect. The effect was time and dose dependent. Inhibitory effect of procyanidins on hepatic mitochondria lipid peroxidation induced by croton oil was also observed. Procyanidins could raise the activity of SOD and decrease the level of MDA. CONCLUSION It was concluded that anti oxidation effect of procyanidins was one important mechanism of cancer chemoprevention.
