Effect of puerarin on action potential and ERP in guinea pig papillary muscles
- VernacularTitle:葛根素对豚鼠心肌细胞动作电位及有效不应期的影响
- Author:
Weina MIAO
;
Yingjun SHEN
;
Xiaorong ZENG
;
Zhifei LIU
;
Fuman YAN
;
- Publication Type:Journal Article
- Keywords:
puerarin;
action potentials(AP);
effective refractory period(ERP)
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the mechanism of puerarin against arrhythmias. METHODS Standard microelectrode intracellular recording technique was used RESULTS ①Puerarin 0 005, 0 01,0 015 mmol?L -1 prolong the action potential duration at 50% and 90% of repolarization (APD 50 ,APD 90 ) respectively APD 50 was prolonged from (176 43?51 37) ms to (192 86?60 82) ms ( n=7, P
