The variation of blood vessel factors on pulmonary hyperation induced by monocrotaline
- VernacularTitle:野百合碱诱发肺动脉高压大鼠血管活性物质的变化
- Author:
Yanni SUN
;
Zhongling LIU
;
- Publication Type:Journal Article
- Keywords:
monocrotaline;
pulmonary hypertension;
endothelin;
nitric oxide;
thromboxane B 2;
6 keto prostagandin F 1?
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explain the variation of blood vessel factors on pulmonary hypertension(PH) induced by monocrotaline(MCT). METHODS Rats were given an injection of MCT ih(60 mg?kg -1 ). The concentration of endothe line(ET), nitric oxide(NO), thromboxane B 2(TXB 2) and 6 keto prostaglandin F 1? (6 keto PGF 1? ) were measured by radioimmunoassay and colorimetric analysis after the model had been set up successfully for 4 wk. RESULTS MCT either raised 6 keto PGF 1? and NO or prevented the progression of ET and TXB 2. CONCLUSION The mechanism of PH induced by MCT probably associated with the variation of those blood vessel factors.
