The effects of cyclophosphamide on bone histomorphometry in rats
- VernacularTitle:环磷酰胺对大鼠骨组织形态计量学的影响
- Author:
Yongdong WANG
;
Tie WU
;
Xiaoqing LIU
;
Liao CUI
;
Qingnan LI
;
- Publication Type:Journal Article
- Keywords:
cyclophosphamide;
osteoporosis;
bone histomorphometry;
rat
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of doses of cyclophosphamide(CP) on bone histomorphometry in rats,and evaluted the rat model of osteoporosis after cyclophosphamide administration. METHOD CP at doses of 1 5, 4 5 and 13 5 mg?kg -1 were given to the rats orally everyday for 15 days respectively.in addition, soldium chloride used as control group. At the end of 15 days, the right distal femur were processed to undecalcified sections at 4um and 8 ?m for histomorphometric analysis. RESULT Trabecullar bone mass at doses of 4 5 and 13 5 mg?kg -1 CP reduced markedly, While dose of 1 5 mg?kg -1 CP has no influence on trabecullar bone mass.CONCLUSION Cyclophosphamide has stronger influences on bone tissue and structure in rats. It can be used to make the rat model of osteoporosis.
